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Updated: Dec 12, 2025
04:29
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
29.3K
Treatment-resistant depression: An overview for psychiatric advanced practice nurses
Brayden N Kameg1, Kirstyn M Kameg2
1University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania.
Perspectives in Psychiatric Care
|August 11, 2020
Summary
Treatment-resistant depression (TRD) management is complex. New neurobiological insights support augmenting pharmacological agents, neuromodulation, and esketamine for TRD remission.
Area of Science:
- Neuroscience
- Psychiatry
Background:
- Treatment-resistant depression (TRD) presents significant management challenges.
- Understanding the neurobiology of depression is crucial for developing effective therapies.
Purpose of the Study:
- To provide an update on the hypothesized neurobiology of depression.
- To describe current and emerging treatment options for patients with TRD.
Main Methods:
- Review of recent neurobiological findings.
- Analysis of pharmacological agents, neuromodulation techniques, and esketamine.
Main Results:
- Neurobiological research supports novel therapeutic strategies for TRD.
- Augmenting pharmacological agents, neuromodulation, and esketamine show promise for remission.
Conclusions:
- Advances in neurobiology inform TRD treatment.
- Psychiatric nurses require expertise in managing complex TRD cases with advanced interventions.
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