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Updated: Dec 12, 2025

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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
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Evolution of SIVsm in humanized mice towards HIV-2
James Curlin1, Kimberly Schmitt1, Leila Remling-Mulder1
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Journal of Medical Primatology
|August 11, 2020
Abstract:
Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T-cell decline as the virus was passaged in humanized mice.

