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Survival analysis in treated plasmablastic lymphoma patients: a population-based study
Jorge A Florindez1, Juan P Alderuccio2, Isildinha M Reis3,4
1Division of Hospital Medicine, Miller School of Medicine, University of Miami, Miami, Florida.
American Journal of Hematology
|August 11, 2020
Summary
Plasmablastic lymphoma (PBL) patients treated with chemotherapy show improved survival, especially with oral primary sites. Long-term survival is achievable for treated PBL patients, with age over 60 linked to poorer outcomes.
Area of Science:
- Hematology
- Oncology
- Epidemiology
Background:
- Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma, predominantly affecting HIV-positive individuals.
- Understanding survival outcomes in chemotherapy-treated PBL patients is crucial for treatment planning and prognosis.
Purpose of the Study:
- To analyze survival outcomes in chemotherapy-treated patients with plasmablastic lymphoma.
- To identify clinical characteristics associated with improved or decreased survival in PBL patients.
Main Methods:
- Retrospective analysis of 248 chemotherapy-treated PBL patients diagnosed between 2010-2016.
- Data sourced from the Surveillance, Epidemiology, and End Results (SEER) 18 registries database.
- Multivariable analysis was used to identify factors associated with overall survival (OS) and lymphoma-specific survival (LSS).
Main Results:
- The 3-year and 5-year overall survival (OS) rates were 54% and 52.8%, respectively.
- Oral primary location was associated with significantly better OS (HR 0.43) and LSS (SHR 0.36).
- Age ≥60 years was associated with shorter LSS (SHR 1.73), while HIV status did not significantly impact survival.
Conclusions:
- Chemotherapy-treated plasmablastic lymphoma patients can achieve long-term survival.
- Oral primary site and younger age are favorable prognostic factors in PBL.
- Further research into optimizing treatment strategies for PBL based on these factors is warranted.
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