Multicentric Exophytic Primary Spinal Cord Glioblastoma Mimicking Teratoma

Primary spinal cord glioblastoma is an extremely rare disease that shows dismal prognosis. Here we report the first case, to our knowledge, of multicentric primary spinal cord glioblastoma presenting with exophytic involvement mimicking teratoma. A 12-year-old girl presented to our hospital with a 6-month history of back pain and progressive paraplegia. Spinal magnetic resonance imaging findings were suspicious for spinal teratoma with cerebrospinal fluid dissemination. The patient underwent laminotomy and laminoplasty from T10-S2 and subtotal resection of the tumor was achieved. Histopathological analysis revealed typical histological indications of glioblastoma. After surgery, the patient underwent further adjuvant therapy consisting of radiotherapy and temozolomide. However, 8 months after surgery, the follow-up magnetic resonance imaging scan revealed tumor recurrence with intracranial dissemination. The patient is still alive at the current stage (9 months after surgery).