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Hydroxyapatite/tannic acid composite coating formation based on Ti modified by TiO2 nanotubes
Lin Qiaoxia1, Zhou Yujie1, Yin Meng1
1Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.
Colloids and Surfaces. B, Biointerfaces
|August 11, 2020
Summary
This study developed a hydroxyapatite/tannic acid coating for titanium implants, significantly enhancing antioxidant activity to improve osseointegration and reduce implant failure.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Nanotechnology
Background:
- Oxidative stress from reactive oxygen species (ROS) impairs bone-implant integration, increasing failure rates.
- Titanium (Ti) implants require enhanced antioxidant properties for better osseointegration.
- Developing functional coatings is crucial for improving implant performance.
Purpose of the Study:
- To create a hydroxyapatite (HA)/tannic acid (TA) composite coating on titanium implants.
- To impart antioxidant activity to titanium implants to improve osseointegration.
- To evaluate the antioxidant capacity and cytocompatibility of the developed coating.
Main Methods:
- Fabrication of titanium dioxide (TiO2) nanotube arrays on Ti substrates via anodization and annealing.
- Formation of TA-Ca coordination complexes on TiO2 nanotubes.
- Coating with hydroxyapatite (HA) nanoparticles via phosphorylation.
- Assessment of antioxidant capacity using total antioxidant capacity assay.
- In vitro evaluation of osteoblast adhesion and proliferation.
Main Results:
- Ordered TiO2 nanotubes (142.23±14.52 nm diameter, 374.17±42.47 nm length) with anatase phase were successfully fabricated.
- HA/TA composite coating demonstrated persistent and strong antioxidant activity.
- The HA/TA coating exhibited excellent cytocompatibility, promoting osteoblast proliferation and adhesion.
Conclusions:
- The developed HA/TA composite coating effectively enhances the antioxidant properties of titanium implants.
- This novel coating strategy shows significant potential for improving osseointegration and reducing implant failure.
- The coating's biocompatibility supports its use in orthopedic applications.
