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Updated: Dec 12, 2025
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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
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Emerging role of non-coding RNAs in allergic disorders
Soudeh Ghafouri-Fard1, Hamed Shoorei2, Mohammad Taheri3
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 11, 2020
Summary
Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play crucial roles in immune responses and allergic disorders. These molecules show promise as therapeutic targets and biomarkers for conditions like asthma and atopic dermatitis.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- Non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are critical regulators of gene expression.
- Dysregulation in ncRNA biogenesis is implicated in the development of immune-related disorders.
- lncRNAs and miRNAs are recognized as key regulators of the immune system.
Purpose of the Study:
- To review the current understanding of ncRNA roles in allergic diseases.
- To explore the potential of ncRNAs as therapeutic targets and biomarkers for allergic disorders.
Main Methods:
- Literature review of studies on non-coding RNAs in allergic conditions.
- Analysis of the biogenesis and function of lncRNAs, miRNAs, and circRNAs.
- Synthesis of data regarding the involvement of ncRNAs in asthma, atopic dermatitis, allergic rhinitis, and urticaria.
Main Results:
- lncRNAs and miRNAs are involved in regulating immune responses and are implicated in allergic disorders.
- circRNAs can interact with miRNAs and affect protein-coding transcript maturation.
- Alterations in ncRNA biogenesis are linked to immune-related disease development.
Conclusions:
- lncRNAs and miRNAs are significant regulators in the context of allergic diseases.
- These non-coding RNAs represent promising therapeutic targets and diagnostic biomarkers for allergic disorders.
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