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Updated: Dec 12, 2025
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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
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Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing
Kevin M Camstra1, Visish M Srinivasan1, Dalis Collins2,3
1Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Neurointervention
|August 12, 2020
Summary
This study demonstrates that canine cerebral vasculature is posterior circulation dominant, making it a viable model for intra-arterial therapies. Flow-directed microcatheters are best for accessing the canine brain
Area of Science:
- Neuroscience
- Vascular Biology
- Translational Medicine
Background:
- Advancing endovascular technology necessitates models for minimally invasive intra-arterial therapies for cerebral diseases.
- A translational model for canine cerebral circulation accessible to microcatheters is needed.
Purpose of the Study:
- To report the experience of catheterizing canine cerebral circulation using microcatheters.
- To present high-resolution angiographic images of canine vascular anatomy.
- To describe arterial branch flow patterns and provide measurements of canine arterial conduits.
Main Methods:
- Cerebral angiography was performed on 10 purpose-bred hounds.
- Measurements of arterial conduits and catheterization data for intracranial arterial branches were obtained.
Main Results:
- Selective and superselective cerebral angiography was successful in all subjects.
- Catheterization of the Circle of Willis was achieved via the posterior circulation in 3 subjects.
- Flow-directed microcatheters reduced arterial tree deformation and improved superselection of intracranial vessels.
- Catheterization via the internal carotid artery was unsuccessful due to tortuosity and vasospasm.
Conclusions:
- Canine cerebral vasculature is predominantly supplied by the posterior circulation.
- Direct cerebral arterial access is best achieved via the posterior circulation using flow-directed microcatheters.
- The canine model is suitable for testing novel intra-arterial cerebral treatments.
