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Chromatin-modifying elements for recombinant protein production in mammalian cell systems

Xiao Guo1,2, Chong Wang3, Tian-Yun Wang1,2

  • 1Department of Biochemistry and Molecular Biology, Xinxiang Medical University, Xinxiang, China.

Critical Reviews in Biotechnology
|August 12, 2020
PubMed
Summary

Optimizing expression vectors with chromatin-modifying elements improves recombinant protein production in mammalian cells. This review summarizes key elements and strategies for enhancing protein expression and stability.

Keywords:
Recombinant proteinUbiquitous chromatin open elementschromatin-modifying elementexpression vectorinsulatorsmammalian cellmatrix attachment regionstabilizing anti-repressor elements

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