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Can prepartum platelet indices be a parameter to predict postpartum hemorrhage?
Emine Öztürk1, Suna Yıldırım Karaca2, Onur İnce3
1Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.
Summary
Antenatal platelet indices can predict postpartum hemorrhage (PPH). Lower pre-delivery mean platelet volume (MPV) is a significant risk factor for PPH, offering a new predictive tool for this common complication.
Area of Science:
- Obstetrics and Gynecology
- Hematology
Background:
- Postpartum hemorrhage (PPH) is a leading cause of maternal mortality globally.
- Platelet indices reflect platelet reactivity and may serve as predictive markers.
Purpose of the Study:
- To investigate if antenatal platelet indices can predict the risk of primary postpartum hemorrhage (PPH).
Main Methods:
- A comparative case-control study of 3207 term pregnant women.
- Platelet indices (platelet count, MPV, PDW, plateletcrit) measured pre-delivery.
- PPH defined as blood loss ≥1000 mL within 24 hours postpartum.
Main Results:
- Lower prepartum mean platelet volume (MPV) and platelet distribution width (PDW) were observed in women with PPH.
- MPV demonstrated high predictive value (AUC 0.823) for PPH with 81% specificity and 69% sensitivity at a cutoff of 10.95 fL.
Conclusions:
- Pre-delivery MPV is a potential novel predictor for postpartum hemorrhage.
- Antenatal platelet indices may aid in identifying women at risk for PPH.
