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Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children

Meiyuan Chen1, Jing Xiao2, Yuan Du2

  • 1Department of Urology, Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong'an Road, Xicheng District, Beijing, 100050, China. Meiyuan.chen@gmail.com.

BMC Urology
|August 12, 2020
PubMed

Insights

In children, elevated non-high-density lipoprotein cholesterol (non-HDL-c) and serum uric acid are linked to urolithiasis. Non-HDL-c may be a key lipid risk factor for pediatric kidney stones.

Area of Science:

  • Pediatric Nephrology
  • Metabolic Disorders
  • Urology

Background:

  • Dyslipidemia is a known risk factor for nephrolithiasis in adults.
  • The association between dyslipidemia and urolithiasis in children is not well-established.

Purpose of the Study:

  • To investigate the relationship between dyslipidemia and urolithiasis in pediatric patients.
  • To identify potential lipid risk factors for urolithiasis in children.

Main Methods:

  • A case-control study was conducted with 58 pediatric patients with upper urinary tract stones and 351 controls.
  • Comparisons included age, BMI, serum calcium, uric acid, glucose, blood lipids, and stone composition.

Main Results:

  • Children with urolithiasis had higher serum uric acid and non-high-density lipoprotein cholesterol (non-HDL-c).
  • Multivariate analysis confirmed non-HDL-c and serum uric acid as significant factors.
  • Non-HDL-c was associated with pure calcium oxalate stones.

Conclusions:

  • Non-high-density lipoprotein cholesterol (non-HDL-c) may be a significant lipid risk factor for urolithiasis in children.
  • Serum uric acid is also elevated in pediatric stone formers.
Abstract

Keywords:
ChildDyslipidemiasNon-HDL cholesterolUrolithiasis

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