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Related Experiment Videos

Captopril-induced cough.

J K Stoller1, A Elghazawi, A C Mehta

  • 1Department of Pulmonary Disease, Cleveland Clinic Foundation.

Chest
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Angiotensin-converting enzyme (ACE) inhibitors, like captopril, can cause a persistent cough. This side effect, though known, is often overlooked in pulmonary medicine, necessitating greater awareness.

Area of Science:

  • Pharmacology
  • Pulmonary Medicine
  • Cardiovascular Therapeutics

Background:

  • Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for cardiovascular conditions.
  • Cough is a known, albeit infrequently discussed, side effect of these drugs.

Observation:

  • Two patient cases illustrate cough associated with ACE inhibitor use.
  • A review of existing literature was conducted to assess the prevalence and characteristics of this adverse effect.

Findings:

  • ACE inhibitor-induced cough is a recognized, yet underreported, adverse drug reaction.
  • The mechanism of cough is likely related to bradykinin accumulation.

Implications:

  • Pulmonary clinicians should consider ACE inhibitors in the differential diagnosis of chronic cough.

Related Experiment Videos

  • Increased awareness may lead to earlier diagnosis and appropriate management of ACE inhibitor-induced cough, improving patient adherence and outcomes.