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Updated: Dec 12, 2025
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Published on: July 2, 2021
Recurrent synovitis of hip and MEFV gene related arthritis in children
Farhad Salehzadeh1, Mehrdad Mirzarahimi2
1Pediatric Rheumatology, Pediatric Department, Bouali Children's Hospital, Ardabil University of Medical Sciences (ARUMS), Ardabil, Iran.
Background:
Recurrent and relapsing arthritis has been proposed to describe a group of arthritis with recurring and periodic nature, in which the joints are intermittently involved. This study reports three non-FMF patients with heterozygous MEFV gene mutations and an extraordinary arthritis as a recurrent synovitis of hip (RSH).
Methods:
During 16-years from 2003 to 2019 at pediatric rheumatologic clinic among 195 recorded files with chronic oligoarthritis, 3 patients with diagnosis of recurrent synovitis of hip (RSH) were reviewed thoroughly. Peripheral blood was collected from patients and the samples were screened for the 12 common MEFV gene pathogenic variants.
Results:
This study included three patients, two female and one male with relapsing idiopathic arthritis that has been located on hip joints as a sole manifestation and pathologic findings of MEFV mutations as follow: A744S, V726A, and R761H.
Conclusion:
On the basis of possible role of MEFV gene in different rheumatic disease, MEFV gene related arthritis may be considered as a background of RSH particularly in Mediterranean area.
Insights
Recurrent synovitis of the hip (RSH) in three patients was linked to heterozygous MEFV gene mutations. This suggests a potential genetic link between MEFV mutations and RSH, particularly in Mediterranean populations.
Area of Science:
- Rheumatology
- Genetics
- Pediatric Rheumatology
Background:
- Recurrent and relapsing arthritis involves intermittent joint inflammation.
- This study investigates three non-Familial Mediterranean Fever (FMF) patients with recurrent synovitis of the hip (RSH).
- These patients presented with heterozygous MEFV gene mutations.
Purpose of the Study:
- To explore the association between MEFV gene mutations and recurrent synovitis of the hip (RSH).
- To identify potential genetic factors contributing to RSH in non-FMF patients.
Main Methods:
- A 16-year retrospective review (2003-2019) of pediatric rheumatology cases.
- Analysis of 195 patient files diagnosed with chronic oligoarthritis.
- Genetic screening of three RSH patients for 12 common MEFV gene pathogenic variants.
Main Results:
- Three patients (2 female, 1 male) diagnosed with RSH were identified.
- RSH was the sole manifestation in these patients, affecting only the hip joints.
- Pathologic MEFV mutations identified were A744S, V726A, and R761H.
Conclusions:
- MEFV gene-related arthritis should be considered a potential cause of RSH.
- This association is particularly relevant in the Mediterranean region.
- Further research into the role of MEFV gene in rheumatic diseases is warranted.
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