Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

153
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
153
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.8K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.8K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

147
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
147
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

131
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
131
Vitamins01:30

Vitamins

2.1K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.1K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

175
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
175

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulating Midwifery Through Manuals: Institutionalization and the Displacement of Traditional Midwives in the 20th-Century South.

Journal of midwifery & women's health·2026
Same author

Implementation of a Community Doula-Hospital Partnership to Improve Access to Linguistically and Racially Concordant Doula Care for Black Birthing People.

Journal of midwifery & women's health·2026
Same author

History of Midwifery at Tuskegee: Vanguards of Midwifery Education.

Journal of midwifery & women's health·2024
Same author

Harmonization of Newborn Screening Results for Pompe Disease and Mucopolysaccharidosis Type I.

International journal of neonatal screening·2023
Same author

Propensity Score Matching Analysis of the Effect of Payer Status on the Survival of Colon Cancer Patients.

Cureus·2021
Same author

Using a Claims-Based Framework to Identify Severe Maternal Morbidities in a Commercially Insured US Population.

The Journal of perinatal & neonatal nursing·2021

Related Experiment Video

Updated: Dec 12, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

662

Educating Parents on Vitamin K Prophylaxis for Newborns.

Sharon L Holley, Katharine Green, Michelle Mills

    Nursing for Women'S Health
    |August 12, 2020
    PubMed
    Summary

    Vitamin K injection is recommended for newborns to prevent vitamin K deficiency bleeding (VKDB), especially for breastfed infants. Nurses play a crucial role in educating parents about this vital newborn prophylaxis.

    Keywords:
    VKDBclottinghemorrhagic disease of the newborninjectionvitamin Kvitamin K deficiency bleedingvitamin K prophylaxis

    More Related Videos

    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
    09:36

    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

    Published on: July 28, 2022

    2.5K
    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
    07:27

    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

    Published on: August 19, 2020

    12.2K

    Related Experiment Videos

    Last Updated: Dec 12, 2025

    Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
    03:19

    Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

    Published on: June 28, 2024

    662
    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
    09:36

    Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

    Published on: July 28, 2022

    2.5K
    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
    07:27

    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

    Published on: August 19, 2020

    12.2K

    Area of Science:

    • Neonatal Medicine
    • Pediatric Hematology

    Background:

    • Vitamin K is essential for blood clotting and preventing vitamin K deficiency bleeding (VKDB) in newborns.
    • Breastfed infants are at higher risk for VKDB.
    • The U.S. FDA has not approved an oral vitamin K for newborns, and missed doses increase VKDB risk.

    Purpose of the Study:

    • To highlight the importance of vitamin K prophylaxis in preventing VKDB in newborns.
    • To emphasize the recommended route of administration and the role of healthcare providers.

    Main Methods:

    • Review of current guidelines and literature regarding vitamin K prophylaxis.
    • Discussion of the risks associated with VKDB and the benefits of prophylactic vitamin K.

    Main Results:

    • Vitamin K injection is the recommended method for VKDB prevention in newborns by the American Academy of Pediatrics.
    • Oral vitamin K options for newborns are limited and not FDA-approved, posing challenges for consistent prophylaxis.

    Conclusions:

    • Vitamin K injection is crucial for preventing VKDB in newborns.
    • Nurses are vital in educating parents about vitamin K prophylaxis and facilitating informed decisions.
    • Ensuring timely administration of vitamin K is critical for infant health.