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Related Experiment Videos

Opiate-induced hypersensitivity to testosterone feedback: pituitary involvement.

P S Kalra1, A Sahu, S P Kalra

  • 1Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610.

Endocrinology
|March 1, 1988
PubMed
Summary

Morphine increases testosterone's feedback sensitivity on luteinizing hormone (LH) release in male rats. This effect appears to stem from reduced pituitary responsiveness to gonadotropin-releasing hormone (GnRH), not altered GnRH release.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Reproductive Biology

Background:

  • Testosterone (T) normally inhibits luteinizing hormone (LH) release via negative feedback.
  • Opioids, like morphine (M), can influence reproductive hormone regulation.
  • The precise mechanism by which morphine modulates testosterone's feedback on LH release is not fully understood.

Purpose of the Study:

  • To investigate the mechanism by which morphine enhances the inhibitory feedback of testosterone on LH release in castrated male rats.
  • To differentiate between effects on LHRH release and pituitary responsiveness to LHRH.

Main Methods:

  • Castrated male rats were treated with varying doses of testosterone (T) and/or morphine (M).
  • In vitro release of gonadotropin-releasing hormone (GnRH) from hypothalamic tissue was measured.

Related Experiment Videos

  • In vivo pituitary LH release in response to GnRH challenge was assessed.

    • Main Results:

    • Morphine did not alter basal or naloxone-induced GnRH release in vitro.
    • Morphine significantly attenuated LH release in vivo in response to GnRH challenge in testosterone-treated rats.
    • The LH response to GnRH was abolished in rats treated with both testosterone and morphine.

    Conclusions:

    • Morphine enhances testosterone's negative feedback on LH release primarily by reducing pituitary responsiveness to GnRH.
    • This reduced pituitary responsiveness may involve direct opioid effects or augmented hypothalamic neurohumoral actions.
    • The findings suggest a complex interplay between opioids, testosterone, and the hypothalamic-pituitary-gonadal axis.