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Acute amnestic syndrome with hippocampal lesion due to influenza B-associated encephalopathy

Kitty Koll1, Susanne Willinger2, Karoline Urlesberger1

  • 1Department of Neurology, Klinik Ottakring - Wilhelminenspital, Montleartstraße 37, 1160, Vienna, Austria.

Wiener Klinische Wochenschrift
|August 12, 2020
PubMed

Insights

Influenza B infection can cause acute encephalopathy, leading to severe amnesia in adults. This case highlights hippocampal lesions and persistent memory deficits despite treatment.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuroimaging

Background:

  • Acute encephalopathy is a rare but serious complication of influenza, especially in adults.
  • Influenza infections can present with diverse neurological manifestations.

Observation:

  • A 77-year-old woman developed complete anterograde and significant retrograde amnesia during an influenza B infection.
  • Cranial MRI revealed hippocampal lesions with restricted diffusion in the acute phase.

Findings:

  • The patient's amnesic syndrome persisted despite treatment with intravenous methylprednisolone and immunoglobulins.
  • Hippocampal lesions on MRI correlated with the observed severe memory deficits.

Implications:

  • This case underscores the potential for severe neurological complications, including amnesia, from influenza B.
  • Further research is needed to understand the mechanisms and optimize treatment for influenza-associated encephalopathy.
Keywords:
Antineuronal antibodiesCytokine stormInfluenza virusNeurotropismViral encephalitis

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