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[The role of metalloproteinases in the development of primary open-angle glaucoma]

D I Svinareva1, M I Churnosov1

  • 1Belgorod State National Research University, Belgorod, Russia.

Vestnik Oftalmologii
|August 12, 2020
PubMed

Insights

Matrix metalloproteinases (MMP) play a key role in primary open-angle glaucoma (POAG) pathogenesis. MMP gene variations are linked to POAG development, affecting extracellular matrix regulation and optic nerve damage.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Extracellular matrix regulation is crucial for ocular health.
  • Matrix metalloproteinases (MMP) are key enzymes involved in matrix remodeling.
  • Dysregulation of MMPs is implicated in various eye pathologies.

Purpose of the Study:

  • To review the role of MMPs in the pathogenesis of primary open-angle glaucoma (POAG).
  • To explore the association between MMP gene polymorphisms and POAG.
  • To understand MMP involvement in ocular tissue changes relevant to glaucoma.

Main Methods:

  • Literature review of studies on MMPs and glaucoma.
  • Analysis of research on MMPs in extracellular matrix regulation.
  • Examination of genetic studies investigating MMP gene polymorphisms in POAG.

Main Results:

  • MMPs are involved in the pathogenesis of various glaucoma types.
  • MMPs contribute to decreased intraocular fluid outflow stability.
  • MMPs play a role in ganglionic apoptosis, optic disc remodeling, and lamina cribrosa changes in POAG.
  • Polymorphisms in MMP-1, MMP-2, and MMP-9 genes are associated with POAG.

Conclusions:

  • Matrix metalloproteinases are significantly implicated in the development and progression of primary open-angle glaucoma.
  • Genetic variations in MMP genes represent potential risk factors for POAG.
  • Targeting MMP activity could offer therapeutic strategies for glaucoma management.
Keywords:
apoptosisextracellular matrixgenesmatrix metalloproteinasesprimary open angle glaucoma

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