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Related Experiment Video

Updated: Jun 12, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

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Published on: November 29, 2015

[Drug-induced toxic optic neuropathy].

O D Ostroumova1,2, E V Chikh1, E V Rebrova1

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Vestnik Oftalmologii
|August 12, 2020
PubMed
Summary

Drug-induced optic neuropathy damages the optic nerve, often due to mitochondrial dysfunction. Early detection and drug cessation are key to potentially reversing vision loss and preventing permanent damage.

Keywords:
adverse drug reactionsamiodarone-associated optic neuropathydrug-induced optic neuropathyethambutoloptic nerve

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Area of Science:

  • Ophthalmology
  • Neurology
  • Toxicology

Background:

  • Drug-induced optic neuropathy is a class of disorders where medications lead to optic nerve degeneration.
  • The exact prevalence remains unstudied, but individual drug risks are documented.
  • Mitochondrial damage and oxidative stress are suspected underlying mechanisms.

Purpose of the Study:

  • To review the pathophysiology, symptoms, and management of drug-induced optic neuropathy.
  • To emphasize the importance of early diagnosis and intervention.

Main Methods:

  • Literature review of drug-induced optic neuropathy.
  • Analysis of pathophysiological mechanisms, clinical presentation, and treatment strategies.

Main Results:

  • Common symptoms include reduced central visual acuity, visual field defects, dyschromatopsia, and optic nerve head edema.
  • Mitochondrial damage and free radical imbalance are implicated in pathogenesis.
  • Timely diagnosis and drug withdrawal are crucial for potential vision recovery.

Conclusions:

  • Early identification and cessation of the causative agent are paramount in managing drug-induced optic neuropathy.
  • While vision often recovers post-discontinuation, irreversible vision loss can occur.
  • Further evidence-based treatments beyond drug withdrawal are limited.