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Related Experiment Video

Updated: Dec 12, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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[Revised multidisciplinary guidelines 'Varicella'; broader indication for post-exposure prophylaxis].

J J A van Kampen1,2, A H W Bruns3, E van Leeuwen4

  • 1Erasmus MC, afd. Viroscience, Rotterdam.

Nederlands Tijdschrift Voor Geneeskunde
|August 12, 2020
PubMed
Summary
This summary is machine-generated.

Updated guidelines recommend administering varicella zoster immunoglobulins (VZIG) for post-exposure prophylaxis (PEP) within ten days of exposure. For perinatal cases, VZIG is advised if maternal chickenpox occurs seven days before or after delivery.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Pediatrics

Background:

  • Chickenpox (varicella-zoster virus) poses risks, particularly in perinatal settings.
  • Previous guidelines for post-exposure prophylaxis (PEP) had different timeframes.
  • Treatment protocols for chickenpox required updating.

Purpose of the Study:

  • To update guidelines for post-exposure prophylaxis (PEP) of varicella-zoster virus (VZV).
  • To revise recommendations for VZIG administration in perinatal chickenpox cases.
  • To introduce a new chapter on chickenpox treatment.

Main Methods:

  • Review and revision of existing clinical guidelines for varicella-zoster virus management.
  • Modification of timeframes for VZIG administration post-exposure.
  • Inclusion of updated treatment strategies for chickenpox.

Main Results:

  • Extended window for PEP with VZIG to ten days post-exposure, from 96 hours previously.
  • Adjusted criteria for VZIG in neonates: maternal chickenpox between 7 days before and 7 days after delivery.
  • A new comprehensive chapter on chickenpox treatment has been incorporated.

Conclusions:

  • Updated guidelines provide a broader timeframe for effective VZIG prophylaxis.
  • Revised perinatal exposure recommendations aim to improve neonatal protection.
  • The inclusion of new treatment information enhances comprehensive VZV care.