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Updated: Dec 12, 2025
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
Published on: September 7, 2022
Design of two complementary copolymers that work as a glue for cell-laden collagen gels
Taihei Nishimoto1, Ko Matsukawa, Kenichi Nagase
1Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. akimoto@cross.t.u-tokyo.ac.jp ryo@cross.t.u-tokyo.ac.jp.
Abstract:
We designed two types of copolymers that play a role of "polymeric glue". They introduced surface adhesive functions to cell-laden collagen gels. The present study realised surface functionalisation of naturally derived hydrogels and suggested a novel method for manipulating living cells. This method is potentially useful for in vitro reconstruction of 3D living tissue since it enabled versatile and cytocompatible hydrogel surface modification by a simple procedure without any special equipment.
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