The microbial coinfection in COVID-19
Xi Chen1,2, Binyou Liao1, Lei Cheng1,2
1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Applied Microbiology and Biotechnology
|August 12, 2020
Summary
Microbial coinfection significantly impacts coronavirus disease 2019 (COVID-19) severity and outcomes. Understanding these coinfections is crucial for improving diagnosis, treatment, and prognosis in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Area of Science:
- Infectious Diseases
- Virology
- Microbiology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, posing a global health challenge, particularly for the elderly.
- Microbial coinfections, including viral, bacterial, and fungal, are increasingly recognized as significant factors in COVID-19 pathogenesis.
- These coinfections complicate diagnosis, treatment, and prognosis, potentially increasing disease severity and mortality.
Purpose of the Study:
- To review the role of microbial coinfections in COVID-19.
- To analyze the impact of coinfections on disease development and outcomes.
- To highlight the importance of diagnosing and managing coinfections in SARS-CoV-2 patients.
Main Methods:
- Literature review and synthesis of existing studies on microbial coinfections in COVID-19.
- Analysis of coinfection types (viral, bacterial, fungal) with SARS-CoV-2.
- Examination of the effects of coinfections on clinical presentation, diagnosis, and prognosis.
Main Results:
- Microbial coinfection is a common and critical factor in COVID-19.
- Coinfections exacerbate COVID-19, leading to more severe symptoms and poorer outcomes.
- Various pathogens, including viruses, bacteria, and fungi, have been identified as coinfecting agents with SARS-CoV-2.
Conclusions:
- Microbial coinfection is a non-negligible factor in COVID-19, influencing disease progression and patient outcomes.
- Coinfections present significant challenges in clinical diagnosis and treatment strategies for COVID-19.
- Comprehensive diagnostic approaches are essential to identify and manage microbial coinfections in SARS-CoV-2 infected individuals.
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