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04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Myocarditis in admitted patients with dengue fever
M Bhatt1, M Soneja2, F A Farooqui3
1Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Infection
|August 12, 2020
Summary
Myocarditis, or heart inflammation, affects 7.1% of hospitalized dengue fever patients. Early detection is crucial as it increases illness severity and hospital stay duration.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Cardiac involvement in dengue fever is frequently underdiagnosed.
- The role of myocarditis in severe dengue's hemodynamic instability is not well understood.
Purpose of the Study:
- To determine the incidence of myocarditis in hospitalized dengue fever patients.
- To investigate the clinical presentation and outcomes of dengue-related myocarditis.
Main Methods:
- A prospective observational study included 182 dengue fever patients (≥14 years).
- Exclusion criteria: medications affecting heart rhythm, pre-existing heart disease, electrolyte abnormalities.
- Baseline ECG, Trop-I, and NT-proBNP were performed. Echocardiography was done for elevated biomarkers. Myocarditis diagnosis followed ESC 2013 criteria.
Main Results:
- Myocarditis was diagnosed in 13 patients (7.1%).
- Myocarditis patients exhibited higher rates of shortness of breath, bleeding, fluid overload, and longer hospital stays.
- ECG abnormalities (24%), elevated biomarkers (15%), and echocardiographic findings (6%) were noted.
Conclusions:
- Myocarditis is a significant complication in hospitalized dengue fever patients.
- Dengue-related myocarditis is associated with increased morbidity and prolonged hospitalization.
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