A simple method of mechanical power calculation: using mean airway pressure to replace plateau pressure

The reference method for mechanical power (MP) calculation proposed by Gattinoni et al. is based on plateau pressure (P_plat) which needs an inspiratory hold. This study aims to introduce and validate a simple surrogate for MP calculation without any intervention in ventilated patients with or without acute respiratory distress syndrome (ARDS). The introduced equation is as:[Formula: see text]where P_mean is mean airway pressure, VE is minute ventilation, PEEP is positive end-expiratory pressure, and T_e/T_i is expiratory-to-inspiratory ratio. 50 patients with ARDS and 50 post-operative patients without ARDS were enrolled. P_mean-derived MP and reference MP were obtained at the inspiratory plateau time (T_plat) of 0 and 0.5 s (s). When T_plat was adjusted from 0 to 0.5 s, higher P_mean [non-ARDS cases: 9.3 (8.8-9.9) cmH₂O versus 8.2 (7.9-8.8) cmH₂O, P < 0.001; ARDS cases: 14 (13-16) cmH₂O versus 13 (11-14) cmH₂O, P < 0.001] and shorter T_e/T_i [non-ARDS cases: 1.4 (1.2-1.7) versus 2.4 (2.0-3.0), P < 0.001; ARDS cases: 1.3 (1.2-1.5) versus 2.5 (2.3-2.9), P < 0.001] were found. At both T_plat levels, the P_mean-derived MP correlated well with the reference MP both in patients with or without ARDS (non-ARDS: slopes = 1.05, 0.94, R² = 0.95, 0.93, bias + 0.76, + 0.51; ARDS: slopes = 1.03, 0.95, R² = 0.96, 0.96, bias + 0.97, + 0.78. P < 0.0001 for all). In patients with or without ARDS, P_mean-derived MP allows rapid and dynamic estimation of mechanical power without any intervention at the bedside.