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Behavioral Phenotyping for Down Syndrome in Mice.

Randall J Roper1, Charles R Goodlett2, María Martínez de Lagrán3

  • 1IUPUI Department of Biology, Indianapolis, Indiana.

Current Protocols in Mouse Biology
|August 12, 2020
PubMed
Summary

This study details behavioral tests for assessing Down syndrome (DS) in mouse models. These methods help translate findings to humans, aiding in understanding cognitive and motor deficits in DS.

Keywords:
Down syndromebehavioral phenotypecognitionmotor behaviorneurodevelopment

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Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Down syndrome (DS) is the leading genetic cause of intellectual disability.
  • DS affects neurodevelopment, motor behavior, and cognition.
  • Mouse models are crucial for studying DS neurological underpinnings and potential treatments.

Purpose of the Study:

  • To describe behavioral tests relevant to DS domains in mouse models.
  • To facilitate translation of mouse model findings to human DS research.
  • To explore new approaches for cognitive assessment in DS.

Main Methods:

  • A neurodevelopmental behavioral screen for preweaning mice.
  • The balance beam test to assess motor function.
  • The Multivariate Concentric Square Field (MCSF) test for locomotion and multiple behavioral phenotypes.

Main Results:

  • The described protocols allow for comprehensive behavioral phenotyping in DS mouse models.
  • Integration of findings from different tests can provide a fuller understanding of cognitive strengths and weaknesses.
  • These methods support the biological plausibility of findings from DS mouse models.

Conclusions:

  • Standardized behavioral assessments are vital for advancing DS research.
  • Translational research using mouse models requires validated and relevant behavioral tests.
  • Future directions include refining cognitive assessments for both mice and humans with DS.