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Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers
Mansoore Esmaili1, Chanelle J Brown2, Rustem Shaykhutdinov1
1Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Overduin@ualberta.ca.
Nanoscale
|August 12, 2020
Abstract:
Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.
