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Updated: Dec 12, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
CONAN: a web application to detect specificity determinants and functional sites by amino acids co-variation network
N J Fonseca1,2, M Q L Afonso2, L Carrijo2
1Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Summary:
CONAN is a web application developed to detect specificity determinants and function-related sites by amino acids co-variation networks analysis, emphasizing local coevolutionary constraints. The software allows the characterization of structurally and functionally relevant groups of residues and their relationship with subsets of sequences by automatic cross-referencing with GO terms, UniprotKb annotations and INTERPRO.
Availability And Implementation:
CONAN is free and open-source, being distributed in the terms of the GPLV3 license. The software is available as a web application and python script versions and can be accessed at http://bioinfo.icb.ufmg.br/conan. We also provide running instructions, the source code and a user guide.
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