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Related Concept Videos

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Related Experiment Video

Updated: Dec 12, 2025

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HMGB1 in kidney diseases.

Zhi Zhao1, Zhizhi Hu1, Rui Zeng1

  • 1Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, China.

Life Sciences
|August 12, 2020
PubMed
Summary
This summary is machine-generated.

High mobility group box 1 (HMGB1), a nuclear protein, plays diverse roles in cellular processes and immune responses. This review explores HMGB1

Keywords:
Acute kidney injuryDamage-associated molecular pattern moleculeHigh mobility group box 1Inflammation

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Area of Science:

  • Molecular Biology
  • Immunology
  • Nephrology

Background:

  • High mobility group box 1 (HMGB1) is a conserved nuclear protein involved in DNA replication, repair, and nucleosome stability.
  • Extracellular HMGB1 functions as a damage-associated molecular pattern (DAMP), triggering immune responses.
  • HMGB1 exhibits distinct roles in the nucleus (DNA regulation) and cytoplasm (autophagy, apoptosis).

Purpose of the Study:

  • To review the multifaceted roles of HMGB1 in various renal diseases.
  • To summarize HMGB1-related pathways implicated in kidney pathologies.
  • To highlight potential therapeutic strategies targeting HMGB1 for renal diseases.

Main Methods:

  • Literature review of studies on HMGB1 in renal disease pathogenesis.
  • Analysis of HMGB1's subcellular functions and immune-modulating properties.
  • Synthesis of current research on HMGB1 pathways and therapeutic interventions.

Main Results:

  • HMGB1's nuclear functions are crucial for DNA maintenance.
  • Cytoplasmic HMGB1 influences cell death and survival pathways.
  • HMGB1 is implicated in the pathogenesis of diverse renal conditions.

Conclusions:

  • HMGB1's dual localization dictates its varied biological functions.
  • Targeting HMGB1 pathways offers potential therapeutic avenues for renal diseases.
  • Further research into HMGB1 modulation may yield novel treatments for kidney disorders.