Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microorganisms and premature labor.

M G Dodson1, S J Fortunato

  • 1Department of Obstetrics and Gynecology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.

The Journal of Reproductive Medicine
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes.

Placenta·2011
Same author

Chorioamnionitis--a complex pathophysiologic syndrome.

Placenta·2009
Same author

Increased bioavailability of TNF-alpha in African Americans during in vitro infection: predisposing evidence for immune imbalance.

Placenta·2007
Same author

Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels.

Annals of human genetics·2007
Same author

IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6.

Placenta·2003
Same author

Interleukin-10 inhibition of gelatinases in fetal membranes: therapeutic implications in preterm premature rupture of membranes.

Obstetrics and gynecology·2001
Same journal

Elective Procedures in Obstetrics and Gynecology During the COVID-19 Pandemic.

The Journal of reproductive medicine·2022
Same journal

Choriocarcinoma in Situ in a Partial Hydatidiform Mole A: Case Report.

The Journal of reproductive medicine·2018
Same journal

Isolated Recurrent Hematotrachelos After Abdominal Myomectomy A Case Report.

The Journal of reproductive medicine·2018
Same journal

Live Birth from Electively Cryopreserved Oocytes: A Feasible Option for Couples Opposed to Embryo Cryopreservation A Case Report.

The Journal of reproductive medicine·2018
Same journal

Prevalence and Risk Factors of Ejaculation Failure on the Day of Operation Among Chinese Males Undergoing Assisted Reproductive Technique Treatments.

The Journal of reproductive medicine·2018
Same journal

Efficacy and Safety of Perioperative Use of Epinephrine for Laparoscopic Myomectomy in Infertile Women with Symptomatic Solitary Intramural Uterine Fibroids A Randomized Clinical Trial.

The Journal of reproductive medicine·2018
See all related articles

Certain bacteria, like Mycoplasma and Chlamydia trachomatis, are linked to premature labor. Prophylactic antibiotics may reduce prematurity rates, and microbial phospholipase A2 or prostaglandins could be involved mechanisms.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Microbiology

Background:

  • Premature labor is a significant concern in obstetrics.
  • Several microorganisms have been frequently isolated from patients experiencing premature labor compared to controls.
  • Silent chorioamnionitis is observed in a notable percentage of premature labor cases.

Purpose of the Study:

  • To investigate the association between various microorganisms and premature labor.
  • To explore the potential role of microbial byproducts in the pathogenesis of premature birth.
  • To review the impact of antibiotic treatment on the incidence of prematurity.

Main Methods:

  • Microbiological cultures to identify organisms in premature labor patients and controls.
  • Review of studies on prophylactic antibiotic treatment efficacy.

Related Experiment Videos

  • Analysis of the association between urinary tract infections (pyelonephritis, asymptomatic bacteriuria) and premature labor.
  • Investigation of microbial production of phospholipase A2 and prostaglandins.

    • Main Results:

    • Organisms such as Mycoplasma, group B Streptococcus, Bacteroides, Neisseria gonorrhoeae, and Chlamydia trachomatis were more prevalent in premature labor patients.
    • Prophylactic antibiotic treatment showed a reduced incidence of prematurity in some studies.
    • Untreated pyelonephritis demonstrated a clear association with premature labor, while the link for asymptomatic bacteriuria and treated pyelonephritis was less defined.
    • Certain microbes can produce phospholipase A2 and prostaglandins, potentially mediating premature labor.

    Conclusions:

    • Specific bacterial and other microbial infections are frequently associated with premature labor.
    • Antibiotic interventions may play a role in preventing premature birth.
    • Microbial enzymes and metabolites, such as phospholipase A2 and prostaglandins, are implicated as potential mechanisms linking infection to preterm delivery.