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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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Key MicroRNA's and Their Targetome in Adrenocortical Cancer

Marthe Chehade1,2, Martyn Bullock1,2, Anthony Glover1,2,3

  • 1Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, NSW 2065, Australia.

Cancers
|August 13, 2020
PubMed

Insights

Adrenocortical carcinoma (ACC) is a rare cancer. MicroRNAs (miRNAs) are implicated in ACC development and may serve as biomarkers or therapeutic targets for this aggressive malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine malignancy with a poor prognosis.
  • Complete surgical resection offers the best survival chance, but ACC recurs in 50% of patients within two years.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression and are implicated in various cancers, including ACC.

Purpose of the Study:

  • To review current knowledge on dysregulated miRNAs in adrenocortical carcinoma tumorigenesis.
  • To summarize the functions and target genes of specific miRNAs involved in ACC.
  • To explore the potential of miRNAs as diagnostic biomarkers and therapeutic targets for ACC.

Main Methods:

  • Literature review of studies on miRNA expression and function in adrenocortical carcinoma.
  • Analysis of high-throughput sequencing data identifying dysregulated miRNAs in ACC.
  • Examination of known miRNA targetome databases and functional studies.

Main Results:

  • Specific miRNAs are significantly dysregulated in ACC and correlate with aggressive tumor phenotypes.
  • These miRNAs regulate key oncogenic pathways involved in ACC development and progression.
  • Identified miRNAs exhibit potential as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • Dysregulated miRNAs play a crucial role in adrenocortical carcinoma tumorigenesis.
  • Targeting specific miRNAs offers a promising avenue for novel therapeutic strategies in ACC.
  • MiRNAs hold potential for development into valuable clinical biomarkers for ACC management.
Keywords:
adrenocortical carcinomamicro RNAnon-coding RNA

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