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Arginine and Endothelial Function.

Jessica Gambardella1,2,3,4, Wafiq Khondkar1, Marco Bruno Morelli1,2

  • 1Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine-Montefiore University Hospital, New York City, NY 10461, USA.

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Summary
This summary is machine-generated.

This review explores how the amino acid arginine impacts blood vessel function and tone. It examines clinical and preclinical data on arginine supplementation for conditions like hypertension and diabetes.

Keywords:
ADMABH4COVID-19L-arginineNADPHargininearginine paradoxblood pressuredietary supplementseNOS uncouplingendothelial dysfunctionendotheliumheart failurehypertensionmyocardial infarctionnitric oxideoxidative stressperipheral artery disease

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Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry

Background:

  • Arginine (L-arginine) is a crucial amino acid.
  • It plays a role in protein synthesis, immune response, urea cycle, and nitric oxide (NO) production.
  • Endothelial function and vascular tone are vital for cardiovascular health.

Purpose of the Study:

  • To systematically review the functional role of arginine in regulating endothelial function and vascular tone.
  • To analyze the effects of arginine supplementation in various cardiovascular and metabolic conditions.

Main Methods:

  • Systematic review of clinical and preclinical studies.
  • Examination of studies investigating arginine supplementation.
  • Analysis focused on hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

Main Results:

  • Arginine supplementation influences endothelial function.
  • Evidence suggests a role in managing vascular tone.
  • Effects vary across different disease states and study types.

Conclusions:

  • Arginine is a key regulator of endothelial function and vascular tone.
  • Supplementation shows potential therapeutic benefits in specific cardiovascular and metabolic conditions.
  • Further research is warranted to optimize arginine's clinical application.