Related Experiment Video
Updated: Dec 12, 2025
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study
Walid El-Naggar1, Douglas McMillan2, Arif Hussain3
1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Dalhousie University, Halifax, Canada. walid.el-naggar@iwk.nshealth.ca.
Objective:
To compare the effect of umbilical cord milking (UCM) vs. early cord clamping (ECC) on cerebral blood flow (CBF).
Method:
Preterm infants <31 weeks' gestation were randomized to receive UCM or ECC at birth. Blood flow velocities and resistive & pulsatility indices of middle and anterior cerebral arteries were measured at 4-6 and 10-12 h after birth as an estimate of CBF.
Results:
Randomization allocated 37 infants to UCM and 36 to ECC. Maternal and antenatal variables were similar. There were no significant differences between groups in middle or anterior CBF velocities and resistive indices at either study time point. CBF variables were not correlated with mean blood pressure, systemic blood flow, or intraventricular hemorrhage.
Conclusions:
In very preterm infants, UCM compared with ECC was not shown to change CBF indices during the first 12 h of age or correlate with other hemodynamic measures or with intraventricular hemorrhage.
Trial Registration:
ClinicalTrials.gov: NCT01487187.
