Simultaneous detection of ethambutol and pyrazinamide with IL@CoFe₂O₄NPs@MWCNTs fabricated glassy carbon electrode

For the first time, we report a novel electrochemical sensor for the simultaneous detection of ethambutol (ETB) and pyrazinamide (PZM) using 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim][BF₄]) ionic liquid (IL) assimilated with multiwalled carbon nanotubes (MWCNTs) decorated cobalt ferrite nanoparticles (CoFe₂O₄NPs) on the surface of glassy carbon electrode (GCE). The surface morphological and electrochemical properties of the IL@CoFe₂O₄NPs@MWCNTs was characterized with X-ray diffraction (XRD), transmission electron microscope (TEM), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR) and cyclic voltammetry (CV), differential pulse voltammetry (DPV) respectively. Moreover, the obtained results of CV demonstrated that the 9-folds enhancement in the electrochemical signals was achieved with IL@CoFe₂O₄NPs@MWCNTs@GCE compared to that of a bare GCE. Additionally, the simultaneous electrochemical detection of ETB and PZM was successfully accomplished using IL@CoFe₂O₄NPs@MWCNTs over a wide-range of concentration with good limit of detection (3S/m) of 0.0201 and 0.010 μM respectively. The findings of this study identify IL@CoFe₂O₄NPs@MWCNTs@GCE has promising abilities of simultaneous detection of ETB and PZM in pharmaceutical formulations.