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Shank-associated RH domain interactor signaling in tumorigenesis

Chong Zeng1, Dan Xiong2, Ketao Zhang3

  • 1Medical Research Center, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde, Foshan, Guangdong 528308, P.R. China.

Oncology Letters
|August 13, 2020
PubMed

Insights

Shank-associated RH domain interactor (SHARPIN) is crucial for inflammation and p53 signaling. This review explores SHARPIN

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • SHARPIN is a key component of the linear ubiquitin chain activation complex.
  • SHARPIN plays essential roles in p53 signaling and inflammatory responses.
  • Previous research indicates SHARPIN's involvement in tumor cell survival, growth, invasion, and tumorigenesis.

Purpose of the Study:

  • To review the biological functions of SHARPIN in the context of its presence or absence.
  • To elucidate SHARPIN's role in activating the canonical NF-κB signaling pathway.
  • To summarize SHARPIN's effects on p53 and other signaling pathways in modulating tumorigenesis.

Main Methods:

  • Literature review of existing studies on SHARPIN.
  • Analysis of SHARPIN's interactions with various signaling molecules and pathways.
  • Synthesis of data on SHARPIN's impact on tumorigenesis.

Main Results:

  • SHARPIN regulates p53 protein poly-ubiquitination.
  • SHARPIN interacts with protein arginine methyltransferase 5 in melanoma cells.
  • SHARPIN modulates ras-associated protein-1 and mediates phosphoinositide 3-kinase/AKT signaling.

Conclusions:

  • SHARPIN is critical for both inflammatory responses and tumor cell functions.
  • Understanding SHARPIN's mechanisms in tumorigenesis is vital.
  • SHARPIN presents potential as a therapeutic target in cancer treatment.
Keywords:
LUBACPRMT5PTENSHARPINp53tumorigenesis

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