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Updated: Dec 12, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Gene expression analysis of primary gingival cancer by whole exome sequencing in thirteen Chinese patients
Guo-Min Liu1,2, Tian-Cheng Lu3,2, Yun Liu1,2
1Department of Orthopedics, The Second Hospital of Jilin University Changchun 130041, Jilin, China.
Objectives:
Early diagnosis of and markers for gingival oral squamous cell carcinoma (OSCC) is important for effective treatment.
Methods:
The current study performed a whole exome sequencing of gingival OSCC tissues in thirteen Chinese patients to explore exonic mutants.
Results:
Eighty-five genes emerged as mutants in patients with primary gingival OSCC. CCL4L1 presented a G>A transversion at chr17 17q12, position 36212480, exon 3. KDM5B presented a T>TA insertion at chr1 1q32.1, position 202766506, exon 6. ANKRD36C presented a C>G transition at chr2 2q11.1, position 95945175, exon 18.
Conclusion:
These three mutants might be new markers of gingival OSCC. The finding may provide new targets to diagnose and treat gingival OSCC.
