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Updated: Dec 12, 2025

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Pediatric Somatic Tumor Sequencing Identifies Underlying Cancer Predisposition

Suzanne P MacFarland1, Kristin Zelley1, Lea F Surrey2,3

  • 1Division of Oncology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

JCO Precision Oncology
|August 13, 2020
PubMed
Summary

Somatic tumor testing identified potential cancer predisposition syndromes in pediatric cancer patients. Over one-third of concerning variants were constitutionally confirmed, aiding diagnosis beyond clinical history alone.

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