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Left atrial size and risk of recurrent ischemic stroke in cardiogenic cerebral embolism

Weiwei Quan1, Xuezhi Yang1, Youyu Li2

  • 1Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Brain and Behavior
|August 13, 2020
PubMed

Insights

Left atrial enlargement (LAE) independently predicts recurrent ischemic stroke in patients with cardiogenic cerebral embolism (CCE). This finding highlights LAE as a crucial risk factor for stroke recurrence in this population.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Left atrial enlargement (LAE) is linked to ischemic stroke and recurrence.
  • Limited data exist on the association between LAE and cardiogenic cerebral embolism (CCE).

Purpose of the Study:

  • To investigate the relationship between left atrial size and the recurrence of ischemic stroke in CCE patients.

Main Methods:

  • Prospective study of 303 CCE patients using transthoracic echocardiography (TTE).
  • Left atrial size measured by left atrial diameter (LAD), LAD/height (LAD/H), and LAD/body surface area (LAD/BSA).
  • One-year recurrent ischemic stroke as the endpoint, analyzed with Cox proportional hazard models.

Main Results:

  • Left atrial size measurements (LAD, LAD/H, LAD/BSA) were independent risk factors for recurrent ischemic stroke.
  • LAD/BSA demonstrated the best predictive effect, with a higher area under the curve (AUC) compared to LAD and LAD/H.
  • Multivariate analysis adjusted for multiple confounders confirmed these associations.

Conclusions:

  • Left atrial enlargement is an independent risk factor for one-year ischemic stroke recurrence in CCE patients.
  • Left atrial size, particularly when normalized for body surface area, is a significant predictor of stroke recurrence.
Abstract

Keywords:
Weiwei Quan is first authorcardiogenic cerebral embolismleft atrial sizerecurrent ischemic stroketransthoracic echocardiography

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