Systematization for female genital anatomic variations.

Area of Science:

• Reproductive Medicine
• Embryology
• Genetics

Background:

• Congenital reproductive system variations manifest clinically during reproductive years, causing functional disorders like infertility.
• Current classification systems struggle to categorize these anatomical variations, complicating surgical treatment.
• Deviant anatomy is defined as variations, not anomalies, in this study.

Purpose of the Study:

• To distinguish female genital anatomical variations for appropriate surgical intervention.
• To develop a clinical analysis of uterovaginal malformations and disorders of sex development.
• To establish a unified systematization for female genital anatomical variations.

Main Methods:

• Retrospective review of 718 uterovaginal malformation cases and 144 disorders of sex development cases.
• Assessment of physical variations using ultrasound, MRI, and laparoscopy.
• Genetic studies for disorders of sex development, with classification based on physical, genetic, and clinical findings.

Main Results:

• A unified systematization for female genital anatomical variations was proposed.
• Classification based on genome (karyotype), gonadal morphology, and internal/external genital anatomy.
• Internal anatomy variations classified into 11 basic types and 24 variants of uterovaginal variations.

Conclusions:

• New classifications offer a framework for clinical management and surgical treatment of female genital anatomical variants.
• Aims to improve reproductive outcomes through standardized classification and treatment.
• Facilitates appropriate surgical strategies based on detailed variant classification.