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Updated: Dec 12, 2025

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Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell

Dayong Yao1, Shunyao Xia1, Chengjun Jin1

  • 1Department of Urology, The First Affiliated Hospital of Harbin Medical University , Harbin, China.

Cell Cycle (Georgetown, Tex.)
|August 14, 2020
PubMed

Insights

A new study reveals that decreased miR-885-5p levels correlate with poor outcomes in advanced renal cell carcinoma (RCC) patients treated with sunitinib, suggesting a novel therapeutic target for overcoming drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Sunitinib is a primary treatment for advanced renal cell carcinoma (RCC).
  • Drug resistance significantly limits sunitinib's clinical effectiveness.
  • Identifying resistance mechanisms and biomarkers is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the role of miR-885-5p in sunitinib resistance in clear cell renal cell carcinoma (ccRCC).
  • To elucidate the molecular mechanisms underlying miR-885-5p dysregulation and its impact on sunitinib sensitivity.

Main Methods:

  • Analysis of miR-885-5p expression in ccRCC patients treated with sunitinib.
  • In vitro and in vivo studies to assess the functional role of miR-885-5p.
  • Investigation of the GATA1/miR-885-5p/PLIN3 regulatory pathway.

Main Results:

  • miR-885-5p was downregulated in ccRCC patients with poor response to sunitinib.
  • Reduced miR-885-5p expression contributed to sunitinib resistance.
  • Sunitinib treatment decreased GATA1, leading to reduced miR-885-5p transcription.
  • miR-885-5p targets PLIN3, and its upregulation promotes lipid droplet formation, decreasing sunitinib sensitivity.

Conclusions:

  • The GATA1/miR-885-5p/PLIN3 pathway is implicated in sunitinib resistance in ccRCC.
  • miR-885-5p may serve as a predictive biomarker for sunitinib treatment.
  • Targeting this pathway offers a potential therapeutic strategy for overcoming sunitinib resistance in ccRCC.
Keywords:
RCCmiR-885-5psunitinib

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