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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Updated: Dec 12, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
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Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

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Stem cells and lung regeneration.

Kalpaj R Parekh1, Janna Nawroth2, Albert Pai1

  • 1Department Surgery, Division of Cardiothoracic Surgery, University of Iowa, Iowa City, Iowa.

American Journal of Physiology. Cell Physiology
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

Regenerating the adult lung requires understanding human lung stem cells. Recent advances in lineage tracing and single-cell RNA sequencing are improving our knowledge for potential lung disease therapies.

Keywords:
airway epitheliumbasal cellscell therapydifferentiationpulmonary neuroendocrine cells

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Area of Science:

  • Pulmonary Medicine
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Lung diseases can potentially be cured by replacing defective airway cells with functional ones.
  • Current lung regeneration strategies are hindered by limited understanding of human lung development and stem cell biology.

Purpose of the Study:

  • To review known stem and progenitor cell populations in the human lung.
  • To compare human and rodent lung stem/progenitor cell differences and their roles in chronic lung disease.
  • To discuss therapeutic prospects for lung regeneration.

Main Methods:

  • Review of existing literature on lung stem/progenitor cells.
  • Analysis of recent breakthroughs including lineage-traced animal models.
  • Examination of single-cell RNA sequencing data from human airway cells.

Main Results:

  • Identification of stem cell subtypes, transition states, and cell markers.
  • Elucidation of pathways controlling stem cell differentiation and plasticity.
  • Insights into species-specific differences between human and rodent lung stem cells.

Conclusions:

  • Advancements in modeling the human lung are crucial for understanding lung regeneration.
  • Targeting endogenous stem cells offers a promising therapeutic approach for lung diseases.
  • Further research into human lung development and stem cell function is essential for therapeutic progress.