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Updated: Dec 12, 2025
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
Short-term PM2.5 exposure and circulating von Willebrand factor level: a meta-analysis
Qingqing Liang1, Mengqi Sun2, Fenghong Wang2
1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China; School of Public Health, Baotou Medical College, Inner Mongolia University of Science & Technology, Baotou 014040, PR China.
Background:
Ambient fine particulate matter (PM2.5) is a major threat to cardiovascular health. Endothelial dysfunction is the initiating event associated with the PM2.5-induced cardiovascular disease (CVD). A sensitive marker of endothelial function-circulating von Willebrand factor (vWF), is an independent predictor of adverse clinical outcome in CVD patients. PM2.5 exposure may cause CVD, but the reports of relationship between short-term PM2.5 exposure and circulating vWF are inconsistent.
Objective:
To explore the influence of short-term PM2.5 exposure on circulating vWF.
Methods:
By using a combination of computer and manual retrieval, a systematic literature retrieval was conducted on PubMed, Cochrane Library, Web of Science, Embase and Scopus databases up to October 2019. The heterogeneity among studies was tested by Stata 12.0, and the pooled %-change (percentage change per 10 μg/m3 increase in PM2.5) and its 95% confidence interval (95%CI) were calculated by using random effect model. Sensitivity analysis and publication bias detection were also carried out.
Results:
12 articles were included in this meta-analysis. Short-term PM2.5 exposure (per 10 μg/m3 increase) was associated with the increased vWF (%-change = 0.41, 95%CI: 0.11-0.71). The pooled effect estimates of subgroup with PM2.5 exposure level < 25 μg/m3 was higher (%-change = 8.26; 95%CI: 1.99-14.53) than that with PM2.5 exposure level ≥ 25 μg/m3 (%-change = 0.36; 95%CI: 0.09-0.63).
Conclusion:
Short-term PM2.5 exposure is associated with the increased circulating vWF. It suggests that short-term PM2.5 exposure causes endothelial dysfunction.
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