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Related Experiment Videos

Delayed type hypersensitivity testing in surgical patients.

L D MacLean1

  • 1Department of Surgery, Royal Victoria Hospital, Montreal, Quebec.

Surgery, Gynecology & Obstetrics
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Delayed-type hypersensitivity (DTH) skin tests can predict sepsis risk in surgical patients. A DTH score, combined with albumin and age, offers powerful insights into patient outcomes and potential immune defects.

Area of Science:

  • Immunology
  • Surgical Medicine
  • Critical Care

Background:

  • Delayed-type hypersensitivity (DTH) skin reactions are utilized in clinical settings.
  • Assessing immune status is crucial for predicting outcomes in surgical patients.
  • Sepsis and mortality are significant concerns in post-surgical care.

Purpose of the Study:

  • To evaluate the utility of DTH skin reactions in identifying surgical patients at risk for sepsis and mortality.
  • To determine the predictive value of a DTH score, serum albumin, and age for sepsis development.
  • To explore the relationship between DTH anergy, malnutrition, and immune defects.

Main Methods:

  • Repeated DTH skin testing during the hospital course to calculate a DTH score.
  • Regression analysis to identify predictors of sepsis and death.

Related Experiment Videos

  • Assessment of DTH response in relation to nutritional status and immune function.

    • Main Results:

    • DTH skin reactions can identify surgical patients at increased risk for sepsis and mortality.
    • A DTH score, serum albumin, and patient age are powerful predictors of sepsis and death.
    • Anergy (lack of DTH response) indicates an immune defect related to lymphokine release, but cannot diagnose malnutrition in individuals.

    Conclusions:

    • Repeated DTH testing and a calculated DTH score enhance the prediction of sepsis risk in surgical patients.
    • Immune defects, identified by anergy, can be potentially corrected by lymphokines, offering future therapeutic possibilities.
    • Immunomodulation of host resistance defects presents a promising avenue for improving outcomes in surgical patients.