Role of hydrogen sulfide in cardiovascular ageing

Area of Science:

• Cardiovascular Science
• Gerontology
• Molecular Biology

Background:

• Cardiovascular diseases (CVDs) are a leading cause of death, with ageing being a primary risk factor.
• Endothelial dysfunction and atherosclerosis are key features of vascular ageing, impacting cardiac function.
• Intracellular mechanisms like the SIRT1/AMPK/PCG1α pathway and oxidative stress are implicated in cardiovascular ageing.

Purpose of the Study:

• To review the role of hydrogen sulfide (H2S) in cardiovascular ageing.
• To explore the link between declining endogenous H2S levels and age-related CVDs.
• To identify H2S as a potential target for promoting healthy cardiovascular ageing.

Main Methods:

• Literature review of studies on H2S, cardiovascular ageing, and related molecular pathways.
• Analysis of evidence connecting endogenous H2S levels with cardiovascular health during ageing.
• Synthesis of current understanding of H2S's influence on intracellular ageing mechanisms.

Main Results:

• Hydrogen sulfide (H2S) emerges as a significant modulator of cellular processes involved in ageing.
• A progressive decrease in endogenous H2S levels is associated with the development of cardiovascular diseases.
• H2S influences key pathways implicated in cardiovascular ageing, including antioxidant and anti-inflammatory responses.

Conclusions:

• Hydrogen sulfide (H2S) is a critical factor in regulating cardiovascular ageing.
• Therapeutic strategies targeting H2S may offer a novel approach to prevent or mitigate age-related cardiovascular diseases.
• Maintaining adequate endogenous H2S levels is crucial for promoting healthy cardiovascular ageing.