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Non-coding RNAs regulate angiogenic processes.

Soudeh Ghafouri-Fard1, Hamed Shoorei2, Mahdi Mohaqiq3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Vascular Pharmacology
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) regulate angiogenesis, a process vital for healing and regeneration but also implicated in diseases like cancer. Understanding ncRNAs offers therapeutic strategies for angiogenesis-related disorders.

Keywords:
AngiogenesisCancerlncRNAmiRNA

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biomedical Science

Background:

  • Angiogenesis is crucial for physiological processes like wound healing and tissue regeneration.
  • Aberrant angiogenesis contributes to diseases including cancer and diabetes mellitus.
  • Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis.

Purpose of the Study:

  • To review the function and characteristics of microRNAs and long non-coding RNAs in regulating angiogenesis.
  • To explore the therapeutic potential of targeting ncRNA-modulated angiogenesis.

Main Methods:

  • Literature review of studies on non-coding RNAs (ncRNAs) and angiogenesis.
  • Analysis of mechanisms by which microRNAs and long non-coding RNAs affect VEGF and other angiogenic factors.
  • Synthesis of current understanding of ncRNA roles in physiological and pathological angiogenesis.

Main Results:

  • MicroRNAs and long non-coding RNAs significantly modulate angiogenesis by regulating VEGF and other angiogenic factors.
  • ncRNAs play roles in both normal physiological angiogenesis and pathological conditions.
  • Dysregulation of ncRNAs is implicated in the pathogenesis of various disorders.

Conclusions:

  • Targeting ncRNA-regulated angiogenesis presents a promising therapeutic strategy for human malignancies.
  • Understanding ncRNAs can enhance tissue regeneration in conditions like arteriosclerosis and limb ischemia.
  • ncRNA-mediated regulation of angiogenesis is a critical factor in numerous physiological and pathological processes.