Related Experiment Video

Updated: Dec 12, 2025

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
07:44

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants

Published on: May 22, 2020

28.1K

Anesthetic Management for a Patient With MECP2 Duplication Syndrome: A Case Report

Yuen-Ling Janíce Choi1, Tsz-Kin Marcus Wong1, Kwok Keung Daniel Ng2

  • 1From the Departments of Anesthesiology.

A&A Practice
|August 14, 2020
PubMed

Insights

Methyl CpG binding protein 2 (MECP2) duplication syndrome is a rare X-linked disorder. Anesthetic management is crucial for patients undergoing procedures, focusing on safe induction and drug selection.

Area of Science:

  • Genetics
  • Neurology
  • Anesthesiology

Background:

  • Methyl CpG binding protein 2 (MECP2) duplication syndrome is a rare X-linked genetic disorder.
  • Core phenotypes include hypotonia, developmental delay, and minimal speech.
  • Refractory epilepsy and recurrent infections are leading causes of mortality.

More Related Videos

Laminectomy and Spinal Cord Window Implantation in the Mouse06:59

Laminectomy and Spinal Cord Window Implantation in the Mouse

Published on: October 23, 2019

12.9K
Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

11.3K

Related Concept Videos

Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
503
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
471