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Related Experiment Videos

Cyclophosphamide in renal transplantation.

R V Yadav1, R Indudhara, P Kumar

  • 1Department of Surgery, Postgraduate Institute of Medical Education, Chandigarh, India.

Transplantation
|February 1, 1988
PubMed
Summary

Cyclophosphamide (CP) offers a safe and effective immunosuppression option for renal transplantation, proving particularly valuable for developing nations due to its affordability and availability compared to other standard treatments.

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Area of Science:

  • Nephrology and Immunology
  • Transplantation Medicine

Background:

  • Renal transplantation success relies heavily on immunosuppression.
  • Azathioprine and prednisolone are standard immunosuppressants.
  • Cyclophosphamide (CP) was previously used but enthusiasm waned.

Purpose of the Study:

  • To evaluate the efficacy and safety of cyclophosphamide (CP) in renal transplantation.
  • To assess CP as an alternative to azathioprine in living-related donor (LRD) renal allotransplantation.

Main Methods:

  • Analysis of 29 living-related donor (LRD) renal allotransplantation recipients.
  • Treatment regimen focused on cyclophosphamide (CP) immunosuppression.

Main Results:

  • Cyclophosphamide (CP) demonstrated safety and effectiveness in renal allotransplantation.

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  • CP is a viable alternative to azathioprine in this context.

    • Conclusions:

    • Cyclophosphamide (CP) is a safe and effective immunosuppressant for renal transplantation.
    • Its availability and lower cost make it significant for developing countries.
    • CP presents a cost-effective alternative to azathioprine and cyclosporine.