Related Experiment Video
Updated: Dec 12, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.2K
Emerging Therapeutic Modalities against COVID-19
Shipra Malik1, Anisha Gupta2, Xiaobo Zhong1
1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.
Pharmaceuticals (Basel, Switzerland)
|August 14, 2020
Summary
This review summarizes therapeutic interventions for SARS-CoV-2 (COVID-19), focusing on clinical trials for small molecules, antibodies, vaccines, and plasma therapies to combat the pandemic.
Area of Science:
- Virology
- Infectious Diseases
- Clinical Pharmacology
Background:
- The rapid global spread of SARS-CoV-2 has necessitated urgent development of effective treatments.
- Numerous therapeutic strategies are under investigation to control the COVID-19 pandemic.
Purpose of the Study:
- To provide a comprehensive overview of current therapeutic modalities being evaluated against SARS-CoV-2 in clinical trials.
- To highlight the landscape of ongoing research for COVID-19 treatments.
Main Methods:
- Systematic review of registered clinical trials for SARS-CoV-2 therapeutics.
- Categorization of therapeutic approaches including small molecules, antibodies, vaccines, and convalescent plasma.
Main Results:
- Approximately 86% of registered clinical trials focus on small molecules or antibodies, often combined with immunomodulators.
- The remaining 14% of trials evaluate vaccines and convalescent plasma therapies for symptom mitigation.
Conclusions:
- A diverse range of therapeutic interventions are being actively explored in clinical trials for SARS-CoV-2.
- Small molecules and antibodies represent the predominant focus in current COVID-19 therapeutic research.
More Related Videos
Related Concept Videos
01:29Microorganisms in Medicine and Therapeutics
770
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
770
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:27Tumor Immunotherapy
1.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.5K
01:19Mesenchymal Stem Cells
5.3K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.3K
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
478
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
478
01:30Cancer Vaccines
861
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
861