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PPARs and Angiogenesis-Implications in Pathology.

Nicole Wagner1, Kay-Dietrich Wagner1

  • 1Université Côte d'Azur, CNRS, INSERM, iBV, 06107 Nice, France.

International Journal of Molecular Sciences
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

Peroxisome proliferator-activated receptors (PPARs) regulate metabolism and are involved in various diseases. This review explores their role in angiogenesis, a process crucial for many pathological conditions.

Keywords:
angiogenesiscancercardiovascular diseaseendometriumendothelial cellsperoxisome proliferator-activated receptorplacenta developmentretinal angiogenesissignaling pathways

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Area of Science:

  • Molecular biology
  • Endocrinology
  • Cell biology

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors regulating metabolism.
  • The PPAR family includes three subtypes: PPARα, PPARβ/δ, and PPARγ.
  • PPARs have distinct tissue-specific expression and functions.

Purpose of the Study:

  • To review the function of PPARs in angiogenesis.
  • To highlight the potential of PPAR modulation in treating diseases involving angiogenesis.

Main Methods:

  • Literature review of studies on PPARs and angiogenesis.
  • Analysis of PPAR subtypes' roles in vascular development and disease.

Main Results:

  • PPARs influence angiogenesis through various mechanisms.
  • PPAR modulation shows therapeutic potential in conditions like cancer and cardiovascular diseases.

Conclusions:

  • PPARs are key regulators of angiogenesis.
  • Targeting PPARs offers a promising therapeutic strategy for angiogenesis-related pathologies.