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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Multivariate association between brain function and eating disorders using sparse canonical correlation analysis.

Hyebin Lee1,2, Bo-Yong Park3, Kyoungseob Byeon1,2

  • 1Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Korea.

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Summary
This summary is machine-generated.

This study links brain function to eating disorder traits using detailed questionnaire data. Specific brain networks associated with control and reward showed distinct relationships with eating behaviors and obesity.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Eating disorders are linked to obesity and brain dysfunction.
  • Previous neuroimaging studies used limited questionnaire data, overlooking fine-grained details.
  • The neural underpinnings of eating disorder behaviors remain underexplored.

Purpose of the Study:

  • To investigate the multivariate association between brain function and eating disorder traits at a detailed question level.
  • To explore the relationship between brain connectivity and specific eating disorder behaviors.
  • To understand the neural basis of eating disorders beyond summary factors.

Main Methods:

  • Retrospective analysis of resting-state functional magnetic resonance imaging (fMRI) data.
  • Utilized data from 284 participants in the enhanced Nathan Kline Institute-Rockland Sample.
  • Employed sparse canonical correlation analysis to link brain region connectivity with eating disorder questionnaire items.

Main Results:

  • Frontoparietal networks (executive and inhibitory control) positively correlated with restraint eating behaviors.
  • Reward system brain regions showed negative associations with eating disorder questions.
  • Inhibitory control brain regions were positively associated with the degree of obesity.
  • Findings were validated in an independent dataset (n=34).

Conclusions:

  • This study provides a fine-grained understanding of brain function in eating disorders by analyzing question-level data.
  • Identified specific neural networks associated with key eating disorder behaviors like restraint and reward processing.
  • Results enhance comprehension of the brain's role in eating disorders and their association with obesity.