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Updated: Dec 12, 2025
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
36.9K
Adipose tissue, immune aging, and cellular senescence.
Daniela Frasca1,2, Bonnie B Blomberg3,4
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA. dfrasca@med.miami.edu.
Seminars in Immunopathology
|August 14, 2020
Summary
Obesity increases inflammation and age-associated diseases by promoting cellular senescence in adipose tissue (AT). Targeting these senescent cells in AT can reduce inflammation and combat age-related conditions.
Area of Science:
- Cellular biology
- Immunology
- Gerontology
Background:
- Obesity is a global health crisis linked to shorter lifespans and increased inflammation.
- Adipose tissue (AT) plays a crucial role in fat storage and acts as an endocrine and immune organ.
- Aging impacts AT composition, immune cell infiltration, and adipocyte function.
Purpose of the Study:
- To review the types and functions of adipose tissue (AT) in mice and humans.
- To examine age-induced changes in AT, including cellular senescence.
- To explore therapeutic strategies targeting senescent cells in AT.
Main Methods:
- Literature review of published data on adipose tissue (AT) and aging.
- Analysis of age-related changes in adipocytes, precursor cells, and immune cells within AT.
- Examination of the senescent-associated secretory phenotype (SASP) in AT.
Main Results:
- Senescent cells accumulate in the AT of aging mice and humans.
- These senescent cells secrete factors that promote local inflammation, oxidative stress, and immune cell infiltration.
- Both adipocytes and immune cells within AT can exhibit senescence.
Conclusions:
- Cellular senescence in AT contributes significantly to age-related inflammation and disease.
- Targeting senescent cells in AT offers a promising therapeutic strategy to mitigate inflammation and age-associated pathologies.
- Interventions aimed at removing senescent cells or inhibiting their pro-inflammatory secretions are effective.
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