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The risk of cardiovascular complications in inflammatory bowel disease

Piotr Czubkowski1, Marcin Osiecki1, Edyta Szymańska2

  • 1Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Childrens' Memorial Health Institute, Warsaw, Poland.

Clinical and Experimental Medicine
|August 14, 2020
PubMed

Insights

Inflammatory bowel disease (IBD) increases cardiovascular disease (CVD) risk, particularly during relapses. Endothelial dysfunction links IBD inflammation to atherosclerosis, but pathways require further research.

Area of Science:

  • Gastroenterology
  • Cardiology
  • Immunology

Background:

  • Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a chronic gastrointestinal disorder.
  • Chronic inflammatory conditions, including IBD, are associated with an elevated risk of cardiovascular complications.
  • Endothelial dysfunction is implicated in atherosclerosis and may bridge IBD-related inflammation and cardiovascular disease (CVD).

Purpose of the Study:

  • To review current concepts and research on the risk of cardiovascular disease (CVD) in patients with inflammatory bowel disease (IBD).
  • To explore potential pathogenetic pathways linking chronic IBD inflammation to cardiovascular risk.

Main Methods:

  • Systematic review of adult and pediatric studies.
  • Analysis of current scientific literature on IBD and cardiovascular disease.

Main Results:

  • Studies indicate an increased risk of cardiovascular complications in individuals with inflammatory bowel disease.
  • Endothelial dysfunction is a potential mechanism connecting IBD and atherosclerosis development.

Conclusions:

  • The relationship between inflammatory bowel disease and cardiovascular disease risk is complex and warrants further investigation.
  • Understanding the pathogenetic pathways is crucial for managing cardiovascular risk in IBD patients.

Keywords:
AtherosclerosisEndothelial dysfunctionInflammatory bowel diseaseIschemic heart disease

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