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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Introduction to Nuclear Reprogramming01:14

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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: Dec 12, 2025

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
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Neurodegenerative Diseases and Cell Reprogramming.

Abeer Sallam1,2, Shaker A Mousa3

  • 1Department of Physiology, Faculty of Medicine, Alexandria University, Governorate, Alexandria, Egypt.

Molecular Neurobiology
|August 14, 2020
PubMed
Summary
This summary is machine-generated.

Stem cell therapy and cell reprogramming show promise for treating neurodegenerative diseases by aiding brain renewal. These advanced methods help direct cell fate toward neural lineages for potential tissue repair.

Keywords:
Cell reprogrammingNeural stem cellsNeural transcriptional factorsNeurodegenerative diseases

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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Neurodegenerative diseases encompass diverse conditions with varying pathologies and progression.
  • While brain cell regeneration is possible, natural processes often fall short in repairing damage from insults.
  • Current therapeutic strategies are exploring innovative approaches beyond traditional methods.

Purpose of the Study:

  • To review recent advancements in stem cell therapies for neurodegenerative diseases.
  • To explore the role of cell reprogramming in directing cell fate toward specific neural lineages.
  • To discuss transcriptional factors involved in neural cell fate determination.

Main Methods:

  • Literature review of stem cell therapies in neurodegenerative disease treatment.
  • Analysis of cell reprogramming techniques for neural lineage induction.
  • Examination of transcriptional factors influencing neural cell fate.

Main Results:

  • Stem cell therapy offers a promising avenue for neurodegenerative disease treatment.
  • Cell reprogramming techniques are being optimized to guide cell differentiation.
  • Specific transcriptional factors play a crucial role in directing neural cell fate.

Conclusions:

  • Stem cell therapy and cell reprogramming represent significant progress in neurodegenerative disease research.
  • Optimizing cell signaling pathways is key to successful neural lineage direction.
  • Understanding transcriptional factors is essential for advancing brain renewal strategies.